Ulf Dettmer, PhD

Dr. Ulf Dettmer is renowned for his innovative approaches in the field of neurology, particularly in the study and treatment of neurodegenerative diseases. As an Assistant Professor of Neurology at Harvard Medical School and Brigham and Women's Hospital, Dr. Dettmer has dedicated his career to unraveling the complexities of Parkinson's disease and related synucleinopathies, including Dementia with Lewy bodies, Multi-System Atrophy, and Alzheimer's disease. Dr. Dettmer's research is distinguished by its interdisciplinary nature, employing a blend of cell biology, biochemistry, protein engineering, microscopy, and high-content imaging and screening techniques. His work primarily focuses on understanding the normal cell biology of alpha-synuclein (alphaS), a protein implicated in these disorders, and identifying the pathological states of alphaS that contribute to disease progression. By transforming these abnormal states into screenable phenotypes, Dr. Dettmer aims to pinpoint factors that can restore proper alphaS homeostasis. A key aspect of Dr. Dettmer's research involves the development of a novel mouse model for Dementia with Lewy bodies and Parkinson's disease. This model serves as a critical tool for testing potential therapeutic interventions that could correct the dysregulated alphaS dynamics observed in these conditions. Through his work, Dr. Dettmer seeks to pave the way for new treatment strategies that could significantly improve the quality of life for individuals affected by these debilitating diseases. Dr. Dettmer's contributions to the field have been recognized through numerous publications in prestigious scientific journals, where he has shared his findings with the broader scientific community. His research not only advances our understanding of synucleinopathies but also holds promise for the development of targeted therapies that could alter the course of these diseases. In addition to his research, Dr. Dettmer is committed to mentoring the next generation of scientists and clinicians. He actively engages in teaching and training activities, fostering an environment of collaboration and innovation within his laboratory and the broader academic community. His dedication to education and research excellence makes him a respected figure in the field of neurology. Dr. Dettmer's work continues to inspire hope for those affected by neurodegenerative diseases, as he tirelessly pursues new avenues for understanding and treating these complex conditions. His passion for discovery and commitment to improving patient outcomes underscore his position as a leader in the field of neurology.