Larry Benowitz

Larry Benowitz, PhD, is a distinguished Professor of Surgery and Ophthalmology at Boston Children's Hospital and the F.M. Kirby Neurobiology Center. With a profound dedication to neuroscience, Dr. Benowitz's research primarily focuses on the intricate mechanisms that lead to cell death and the challenges of regenerative failure following central nervous system (CNS) injuries. His work is pivotal in developing innovative strategies to preserve damaged neurons and facilitate the rewiring of neural circuitry, offering hope for recovery in conditions that were once deemed irreversible. Dr. Benowitz has made significant strides in the field of optic nerve regeneration. His groundbreaking research has demonstrated that controlled inflammation, elevation of cAMP, deletion of the pten gene, and the chelation of mobile zinc can significantly promote axon regeneration and enhance the survival of retinal ganglion cells (RGCs). These findings have opened new avenues for therapeutic interventions aimed at restoring vision and neural function. Currently, Dr. Benowitz's research delves into the complex intercellular signaling networks that govern myelination and synaptic changes. He is also exploring the potential of gene therapy as a means to restore vision, a promising frontier in ophthalmology and neurology. His work is not only advancing our understanding of the biological processes involved but also paving the way for practical applications that could transform patient care. In addition to his focus on optic nerve regeneration, Dr. Benowitz is investigating the role of microglia in the death of RGCs within glaucoma models. His research aims to unravel the contributions of these immune cells to neurodegenerative processes, potentially leading to novel therapeutic targets for glaucoma, a leading cause of blindness worldwide. Dr. Benowitz's interests extend to the study of inosine, a naturally occurring compound, and its role in promoting recovery in models of stroke and spinal cord injury. His work in this area seeks to harness the regenerative potential of inosine to improve outcomes for patients suffering from these debilitating conditions. Through his comprehensive approach, Dr. Benowitz is contributing to a deeper understanding of CNS injury and repair, with the ultimate goal of enhancing recovery and quality of life for affected individuals.