John Flanagan, PhD

John Flanagan, PhD, is a distinguished Professor of Cell Biology at Harvard Medical School, where he is focused on real-world applications of molecular and cellular biology to unravel the complexities of neuronal development and regeneration. His research delves into the intricate cell-cell signaling mechanisms that are pivotal in the formation, degeneration, and regeneration of neuronal connections. By exploring the molecular pathways that guide axons during development, Dr. Flanagan aims to elucidate how these pathways establish precise patterns of axonal connections. Dr. Flanagan's work is particularly centered on the interaction between receptors and their ligands, examining how these interactions translate extracellular guidance cues into cellular responses. This research is crucial for understanding the fundamental processes that underpin neuronal connectivity and has significant implications for developing therapeutic strategies for neurodegenerative diseases and injuries. In addition to his work on axon guidance, Dr. Flanagan investigates the regulation of mRNA translation and its impact on synapse plasticity. His studies in this area aim to uncover how translational control contributes to the dynamic changes in synaptic strength and structure, which are essential for learning and memory. Through his comprehensive approach, Dr. Flanagan is advancing our understanding of the molecular biology of neurons and paving the way for innovative treatments in neuroscience. With a commitment to bridging basic science with clinical applications, Dr. Flanagan's research continues to push the boundaries of what is known about neuronal development and regeneration. His contributions to the field are not only expanding our knowledge of cellular and molecular mechanisms but also offering hope for novel interventions in neurological disorders.