Dorthe Schaue

Professor Dorthe Schaue emphasizes the importance of advancing our understanding of radiation oncology and its implications for tissue repair and radioresistance. As an Adjunct Professor in Radiation Oncology at the University of California, Los Angeles (UCLA), she has dedicated her career to exploring the intricate mechanisms that govern cellular responses to radiation, with a particular focus on improving therapeutic outcomes. Professor Schaue's research is at the forefront of investigating the role of pyruvate kinase isoforms in glioblastoma radioresistance, a critical area of study that seeks to enhance the efficacy of radiation therapy in treating this aggressive form of brain cancer. Her work delves into the molecular pathways that contribute to the resistance of cancer cells to radiation, aiming to identify potential targets for therapeutic intervention. In addition to her work on glioblastoma, Professor Schaue has also conducted significant research on the effects of total marrow irradiation on organ damage and tissue repair in both young and old mice. This research provides valuable insights into the age-related differences in tissue response to radiation, which is crucial for developing age-specific treatment strategies that minimize collateral damage while maximizing therapeutic benefits. Through her contributions to the field, Professor Schaue continues to push the boundaries of knowledge in radiation oncology, striving to improve patient outcomes and enhance the quality of life for those undergoing radiation therapy. Her work not only advances scientific understanding but also holds promise for translating research findings into clinical practice.