Hua Linda Cai

Professor Hua Linda Cai is a distinguished faculty member at the University of California, Los Angeles, renowned for her exceptional contributions to the fields of Anesthesiology and Medicine. Her research is primarily focused on unraveling the complex mechanisms underlying vascular remodeling, aging, and diabetes. With a keen interest in the role of oxidative stress in vascular diseases, Professor Cai's work is pivotal in advancing our understanding of these critical health issues. Central to her research is the exploration of Sirtuin 2, a protein that plays a significant role in vascular remodeling. Professor Cai's investigations delve into how Sirtuin 2 influences the restoration of coronary microvascular function, particularly in models of type 2 diabetes. Her studies on diabetic mice have provided valuable insights into the potential therapeutic targets for improving vascular health in diabetic patients. In addition to her work on Sirtuin 2, Professor Cai is deeply engaged in examining the dysfunction of endothelial nitric oxide synthase (eNOS) and its implications for vascular health. She investigates the roles of NADPH oxidases, tetrahydrobiopterin, and nitric oxide in the processes of vascular remodeling and neointimal formation. Her research aims to elucidate the intricate pathways that contribute to vascular diseases, with the ultimate goal of identifying novel strategies for prevention and treatment. Professor Cai's dedication to her research is matched by her commitment to mentoring the next generation of scientists. Her work not only contributes to the scientific community but also inspires her students and colleagues to pursue excellence in their own research endeavors. Through her groundbreaking studies, Professor Cai continues to make significant strides in the field of vascular biology, paving the way for innovative approaches to combat vascular diseases.