Dohun Pyeon

Professor Dohun Pyeon is a distinguished faculty member in the Department of Microbiology and Molecular Genetics at Michigan State University, where he focuses on interdisciplinary studies in immunotherapy and virus-host interactions. His research is particularly centered on HPV-associated cancers, aiming to unravel the complex mechanisms that drive these diseases and to develop innovative therapeutic strategies. Dr. Pyeon's groundbreaking work has demonstrated that restoring the expression of the chemokine Cxcl14 can significantly suppress tumor growth by effectively recruiting immune cells to the tumor microenvironment. This discovery has opened new avenues for his lab, which is actively investigating the mechanisms behind CXCL14-mediated tumor suppression. The ultimate goal is to leverage these findings to create novel immunotherapies that could revolutionize the treatment of HPV-associated cancers. In addition to his work on chemokines, Dr. Pyeon has made significant contributions to understanding the role of the interferon-inducible cytidine deaminase APOBEC3A. His research has shown that APOBEC3A acts as a restriction factor against HPV infection, providing a potential target for therapeutic intervention. His lab is further exploring the implications of APOBEC3A in somatic mutagenesis and cancer progression, aiming to uncover how these processes contribute to the development and advancement of cancer. Through his research, Dr. Pyeon is dedicated to advancing the field of cancer biology and immunotherapy, with a particular focus on the interplay between viruses and their host organisms. His work not only enhances our understanding of HPV-associated cancers but also holds promise for the development of effective treatments that could improve patient outcomes.