Linda J. Pike

Professor at Biochemistry and Molecular Biophysics, Washington University in St Louis5 Followers

Linda J. Pike specializes in cutting-edge techniques for elucidating the molecular mechanisms underlying cellular signaling pathways. As a prominent faculty member at Washington University School of Medicine, she holds the esteemed positions of Alumni Endowed Professor and Professor of Biochemistry and Molecular Biophysics. Her research is primarily focused on the intricate dynamics of growth factors and ErbB receptors, which play a crucial role in cell communication and regulation. Pike has made significant strides in advancing our understanding of the epidermal growth factor receptor (EGFR), a critical component in numerous cellular processes. Her work has shed light on the structural and functional aspects of EGFR, contributing to the broader field of cell signaling and its implications in health and disease. Her research interests also extend to phosphatidylinositol and polyphosphoinositide metabolism, which are vital for cellular signaling and function. With an impressive portfolio of over 190 peer-reviewed publications, Linda J. Pike's research has garnered widespread recognition, amassing over 8600 citations. Her scholarly contributions have not only enriched the scientific community's knowledge but have also paved the way for potential therapeutic advancements in treating diseases related to aberrant cell signaling. Beyond her research, Pike is deeply committed to education and mentorship. She actively engages with students, fostering an environment of inquiry and discovery. Her dedication to mentoring the next generation of scientists is evident in her involvement in various academic programs and initiatives aimed at nurturing young talent. Linda J. Pike's collaborative spirit is reflected in her numerous partnerships with researchers across diverse disciplines. These collaborations have enabled her to approach scientific questions from multiple angles, enhancing the depth and breadth of her research. Her interdisciplinary approach underscores the importance of teamwork in advancing scientific knowledge and addressing complex biological challenges.

Research Interests

Molecular mechanisms Cellular signaling pathways Growth factors ErbB receptors Epidermal growth factor receptor Structure and function of EGFR Biochemistry Molecular biophysics

Publications

1 - Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system,Proceedings of the National Academy of Sciences

Jennifer L. Macdonald , Linda J. Pike ,

, 112-117, 2008-01-08

2 - Negative Cooperativity in the EGF Receptor,The FASEB Journal

Linda Joy Pike ,

, 2009-04-01

3 - Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging,Proceedings of the National Academy of Sciences

Jennifer L. Macdonald-Obermann , David Piwnica-Worms , Linda J. Pike ,

, 137-142, 2011-12-21

4 - Targeting the Dimerization of EGFR,The FASEB Journal

Rob Yang , Linda Pike , Garland Marshall ,

, 2008-03-01

5 - Negative co-operativity in the EGF receptor,Biochemical Society Transactions

Linda J. Pike ,

, 15-19, 2012-01-19

6 - Kinetics of EGF receptor dimer formation,The FASEB Journal

Katherine S Yang , Linda J Pike ,

, 2008-03-01

7 - Lipid rafts: heterogeneity on the high seas,Biochemical Journal

Linda J. PIKE ,

, 281-292, 2004-03-01

8 - Faculty Opinions recommendation of Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2016-07-08

9 - Faculty Opinions recommendation of Conformational coupling across the plasma membrane in activation of the EGF receptor.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2013-02-15

10 - Faculty Opinions recommendation of Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2012-10-19

11 - Faculty Opinions recommendation of Architecture and membrane interactions of the EGF receptor.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2013-02-07

12 - Faculty Opinions recommendation of Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2013-03-27

13 - Faculty Opinions recommendation of Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2012-05-14

14 - Faculty Opinions recommendation of Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2012-04-10

15 - Faculty Opinions recommendation of Molecular basis for multimerization in the activation of the epidermal growth factor receptor.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2016-05-18

16 - Faculty Opinions recommendation of Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

, 2013-05-09

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