Nicholas Zachos

Associate Professor at Cell Biology, Vanderbilt University0 Followers

Professor with a deep interest in the intricate mechanisms of cellular processes, Nicholas Zachos serves as an Associate Professor of Surgery and Cell and Developmental Biology at Vanderbilt University. His academic journey is marked by a commitment to exploring the complexities of cell biology, contributing to the understanding of cellular functions and their implications in medical science. At Vanderbilt, he engages in both teaching and research, fostering an environment where innovative ideas and scientific inquiry thrive. His work not only enhances the academic community but also holds potential for significant advancements in the field of surgery and developmental biology.

Research Interests

Cellular processes cell biology developmental biology surgical advancements

Publications

1 - Coronin 1A is Uniquely Expressed in the Human Follicle Associated Epithelium and is Required For Human M Cell Maturation and Function,The FASEB Journal

Janet Staab , Michele Doucet , Rachel Latanich , Wayne I. Lencer , Nicholas C. Zachos ,

, 2022-05-01

2 - Enterohemorrhagic E. coli (EHEC) Secreted Serine Protease EspP‐Induced Injury and Regeneration is Guided by Desert Hedgehog and WNT2B in Human Colonoids,The FASEB Journal

Julie In , Jianyi Yin , Roger Atanga , Nicholas Zachos , Mark Donowitz , Olga Kovbasnjuk ,

, 1-1, 2020-04-01

3 - Epithelial and neutrophil interactions and coordinated response toShigellain a human intestinal enteroid-neutrophil co-culture model,

Jose M. Lemme-Dumit , Michele Doucet , Nicholas C. Zachos , Marcela F. Pasetti ,

, 2020-09-04

4 - Co‐Culture System of Human Enteroids/Colonoids with Innate Immune Cells,Current Protocols in Immunology

Janet F. Staab , Jose M. Lemme‐Dumit , Rachel Latanich , Marcella F. Pasetti , Nicholas C. Zachos ,

, 2020-11-09

5 - Abstract IA008: Modeling immune-epithelial interactions in health and disease using human intestinal enteroid co-cultures,Cancer Research

Nicholas C. Zachos ,

, IA008-IA008, 2022-12-01

6 - PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells,American Journal of Physiology-Cell Physiology

Nicholas C. Zachos , Luke J. Lee , Olga Kovbasnjuk , Xuhang Li , Mark Donowitz ,

, C266-C275, 2013-08-01

7 - Regulation of Intestinal Electroneutral Sodium Absorption and the Brush Border Na+/H+ Exchanger by Intracellular Calcium,Annals of the New York Academy of Sciences

Nicholas C. Zachos , Olga Kovbasnjuk , Mark Donowitz ,

, 240-248, 2009-05-01

8 - Recovery of Infectious Human Norovirus GII.4 Sydney From Fomites via Replication in Human Intestinal Enteroids,Frontiers in Cellular and Infection Microbiology

Katie N. Overbey , Nicholas C. Zachos , Caroline Coulter , Joseph Jacangelo , Kellogg J. Schwab ,

, 2021-07-07

9 - A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions,Scientific Reports

Gaelle Noel , Nicholas W. Baetz , Janet F. Staab , Mark Donowitz , Olga Kovbasnjuk , Marcela F. Pasetti , Nicholas C. Zachos ,

, 2017-03-27

10 - MOLECULAR PHYSIOLOGY OF INTESTINAL N+/H+ EXCHANGE,Annual Review of Physiology

Nicholas C. Zachos , Ming Tse , Mark Donowitz ,

, 411-443, 2005-03-17

11 - NHERF family and NHE3 regulation,The Journal of Physiology

Mark Donowitz , Boyoung Cha , Nicholas C. Zachos , Christopher L. Brett , Annu Sharma , C. Ming Tse , Xuhang Li ,

, 3-11, 2005-08-01

12 - Epithelial and Neutrophil Interactions and Coordinated Response toShigellain a Human Intestinal Enteroid-Neutrophil Coculture Model,mBio

Jose M. Lemme-Dumit , Michele Doucet , Nicholas C. Zachos , Marcela F. Pasetti ,

, 2022-06-28

13 - Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model,Infection and Immunity

Sridevi Ranganathan , Michele Doucet , Christen L. Grassel , BreOnna Delaine-Elias , Nicholas C. Zachos , Eileen M. Barry ,

, 2019-04-01

14 - Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions,Scientific Reports

Gaelle Noel , Nicholas W. Baetz , Janet F. Staab , Mark Donowitz , Olga Kovbasnjuk , Marcela F. Pasetti , Nicholas C. Zachos ,

, 2017-05-03

15 - Faculty Opinions recommendation of Adult stem cells in the small intestine are intrinsically programmed with their location-specific function.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Nicholas Zachos ,

, 2014-05-12

16 - Faculty Opinions recommendation of De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Nicholas Zachos ,

, 2014-05-12

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