Jeffrey Agar

Dr. Jeffrey Agar has a profound understanding of the intricate mechanisms underlying neurodegenerative diseases, with a particular focus on amyotrophic lateral sclerosis (ALS) and Parkinson's disease. As an Associate Dean and Associate Professor at Northeastern University, he holds appointments in the Bouvé College of Health Sciences, College of Science, and the Center for Drug Discovery. His research is at the forefront of exploring post-translational modifications of proteins and the alterations in protein, peptide, and lipid expression associated with these debilitating conditions. Dr. Agar's work is particularly notable for its emphasis on the structural and toxic effects of these molecular changes. He has developed a groundbreaking physicochemical and structural model that implicates the aggregation and destabilization of Cu-Zn superoxide dismutase (SOD1) as significant risk factors for familial ALS. This model has paved the way for the development of potential therapeutic interventions, including a promising drug candidate for ALS that is currently under investigation. In addition to his research on ALS, Dr. Agar's lab is renowned for its pioneering contributions to the field of top-down mass spectrometry. This advanced analytical technique allows for the detailed examination of protein modifications and interactions, providing invaluable insights into the molecular underpinnings of neurodegenerative diseases. His innovative approach has significantly advanced our understanding of how these diseases progress at the molecular level. Dr. Agar's research interests extend to the study of peptide and lipid expression, further broadening the scope of his investigations into the complex biochemical pathways involved in neurodegeneration. His work has been instrumental in identifying key molecular targets for therapeutic intervention, offering hope for the development of effective treatments for these challenging conditions. Through his dedication to advancing scientific knowledge and his commitment to improving patient outcomes, Dr. Agar has established himself as a leading figure in the field of neurodegenerative disease research. His contributions continue to inspire and drive progress in the quest to unravel the mysteries of these devastating disorders.