Rachel Buchsbaum

Chair and Professor at Genetics, Molecular and Cellular Biology, Tufts University0 Followers

Rachel Buchsbaum takes a creative approach to solving problems in the field of cancer biology, with a particular focus on the intricate signal transduction pathways that drive cancer cell growth and metastasis. As the Jane F. Desforges Chair of Hematology and Oncology and a Professor of Medicine at Tufts University, she is at the forefront of research exploring the complexities of the Rac protein and its role in cancer progression. Dr. Buchsbaum's research is centered on the regulation of the Tiam1/Rac signaling network, a critical pathway in both normal and malignant cells. Her work aims to unravel how these signaling mechanisms influence the interactions between tumor cells and their surrounding microenvironment, providing insights that could lead to novel therapeutic strategies. Her academic journey began with a Bachelor of Arts degree from Harvard University in 1980, followed by a Doctor of Medicine degree from Cornell University in 1985. Throughout her career, Dr. Buchsbaum has been dedicated to advancing our understanding of cancer biology, contributing significantly to the field through her innovative research. In addition to her research, Dr. Buchsbaum is committed to mentoring the next generation of scientists and clinicians, fostering an environment of inquiry and discovery at Tufts University. Her work not only enhances our understanding of cancer but also paves the way for the development of targeted therapies that could improve patient outcomes. Dr. Buchsbaum's contributions to the field have been recognized through various accolades and publications, reflecting her impact on both the scientific community and the broader field of oncology. Her dedication to exploring the molecular underpinnings of cancer continues to inspire her colleagues and students alike.

Research Interests

Cancer biology Signal transduction pathways Cancer cell growth Metastasis Rac protein Tiam1/Rac signaling network Tumor microenvironment interactions Hematology Oncology

Publications

1 - Supervised Machine Learning Algorithms Using Patient Related Factors to Predict in-Hospital Mortality Following Acute Myeloid Leukemia Therapy,Blood

Nauman Saleem Siddiqui , Andreas Klein , Amandeep Godara , Cindy Varga , Rachel J. Buchsbaum , Michael C. Hughes ,

, 3435-3435, 2019-11-13

2 - Abstract 973: Tumor-associated fibroblasts induce long-term changes in breast cancer invasion, cancer stem cell populations, and metastasis through modulation of the Tiam1-ostepontin pathway,Cancer Research

Kun Xu , Xuejun Tian , Stephen P. Naber , Sun Oh , Charlotte Kuperwasser , Rachel J. Buchsbaum ,

, 973-973, 2014-10-01

3 - Predicting In-Hospital Mortality After Acute Myeloid Leukemia Therapy: Through Supervised Machine Learning Algorithms,JCO Clinical Cancer Informatics

Nauman S. Siddiqui , Andreas Klein , Amandeep Godara , Rachel J. Buchsbaum , Michael C. Hughes ,

, 2022-12-01

4 - Network meta-analysis of adjuvant chemotherapy in early breast cancer.,Journal of Clinical Oncology

Preethi John , Raveendhara R Bannuru , Joshua T. Cohen , Rachel J. Buchsbaum , John Kalil Erban ,

, e12071-e12071, 2017-05-20

5 - Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells,Journal of Cell Science

Jiewei Liu , Kun Xu , Maya Chase , Yuxin Ji , Jennifer K. Logan , Rachel J. Buchsbaum ,

, 376-386, 2012-01-15

6 - Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go,Cancers

Rachel Buchsbaum , Sun Oh ,

, 19, 2016-01-27

7 - Faculty Opinions recommendation of A genetically encoded photoactivatable Rac controls the motility of living cells.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2009-09-16

8 - Faculty Opinions recommendation of The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2019-02-10

9 - Faculty Opinions recommendation of Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2016-04-14

10 - Faculty Opinions recommendation of miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2011-01-28

11 - Faculty Opinions recommendation of TIAM1 variants improve clinical outcome in neuroblastoma.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2017-09-18

12 - Faculty Opinions recommendation of Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2010-08-18

13 - Faculty Opinions recommendation of Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2010-05-25

14 - Faculty Opinions recommendation of Cooperative activation of PI3K by Ras and Rho family small GTPases.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2012-06-28

15 - Faculty Opinions recommendation of Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2011-08-04

16 - Faculty Opinions recommendation of Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells.,Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Rachel Buchsbaum ,

, 2012-01-17

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