Malavika Raman

Contributing to thought leadership in the field of molecular biology, Malavika Raman serves as an Associate Professor in Developmental, Molecular, and Chemical Biology at Tufts University School of Medicine. Her research is centered on the intricate mechanisms of protein homeostasis within cells, with a particular emphasis on the VCP AAA-ATPase's role in the degradation of ubiquitin-modified substrates. Through her work, she seeks to unravel the complexities of how VCP influences various cellular processes, which has significant implications for understanding neurodegenerative disorders and cancer. Raman's research delves into the DNA damage responses and the critical pathways involved in maintaining cellular integrity. Her investigations into VCP's mechanism of action are pivotal in identifying novel targets that could lead to therapeutic interventions. By exploring the intersection of protein homeostasis and disease, she aims to shed light on the underlying causes of VCP dysfunction in human disorders, offering potential pathways for treatment and prevention. Her work extends to the study of ER-associated degradation and autophagy, where she examines how these processes contribute to the maintenance of cellular health. By focusing on the degradation pathways, Raman's research provides insights into how cells manage stress and maintain balance, which is crucial for preventing the onset of various diseases. Malavika Raman's contributions to the field are not only advancing scientific understanding but also paving the way for new approaches in tackling complex diseases. Her dedication to uncovering the molecular underpinnings of protein homeostasis reflects her commitment to improving human health through innovative research. As she continues to explore the vast landscape of molecular biology, her work remains at the forefront of scientific discovery, offering hope for breakthroughs in the treatment of neurodegenerative disorders and cancer.