Igor Dolgalev

Assistant Professor at Medicine, New York University9 Followers

Professor pursuing advances in understanding the intricate mechanisms of the immune system, Igor Dolgalev is an Assistant Professor in the Department of Medicine at NYU Grossman School of Medicine. With a PhD from New York University, he has dedicated his career to exploring the complexities of immunology, particularly in the context of cancer and chronic inflammatory diseases. At the helm of the Cellular Analytics Laboratory, Professor Dolgalev employs cutting-edge techniques to unravel the cellular and molecular underpinnings of immune responses. His research is pivotal in identifying novel therapeutic targets and improving treatment strategies for patients suffering from these debilitating conditions. His work not only contributes to the academic community but also has significant implications for clinical practices. Professor Dolgalev's commitment to advancing the field of immunology is reflected in his numerous publications and collaborations with fellow researchers. His passion for science and education is evident in his mentorship of students and young scientists, fostering the next generation of researchers in the field of medicine.

Research Interests

Immunology Cancer Immunology Chronic Inflammatory Diseases Cellular Analytics Immune System Mechanisms Therapeutic Targets Molecular Immunology

Publications

1 - Identification of Old HSCs with Preserved Self-Renewal and Long-Term Reconstitution Potential,Blood

Harold K. Elias , Joseph Y. Shin , Mohamed A.E. Ali , Sohini Chakraborty , Caryn J. Ha , Igor Dolgalev , Colin Konishi , Isabel Beerman , Christopher Y. Park ,

, 2479-2479, 2019-11-13

2 - Using Whole Exome Sequencing in Pediatric Acute Lymphoblastic Leukemia Germline, Diagnosis, and Relapse Trios to Discover Novel Relapse Enriched Mutations for Clonal Backtracking By Ddpcr,Blood

Jason Saliba , Nikki Ann Evensen , Julia Meyer , Igor Dolgalev , Daniel Newman , Ashfiyah Chowdhury , Jacob Nersting , Jinhua Wang , Kjeld Schmiegelow , William L. Carroll ,

, 4085-4085, 2016-12-02

3 - Abstract B062: Low dose dual epigenetic therapy utilizing hypomethylating agents and HDAC inhibitors prolong survival in an orthotopic PDAC model and alter the tumor microenvironment,Cancer Research

Stephen Muzyka , Arturo Orlacchio , Amanda Ackermann , Yasmine Chinda , Yoona Shim , Igor Dolgalev , Tamas Gonda ,

, B062-B062, 2024-09-15

4 - Abstract B87: Genomic complexity and BRAF/MEK-dependence in V600E BRAF mutant melanoma,Molecular Cancer Therapeutics

Feng Xing , Yogindra Persaud , Christine Pratilas , Manickam Janakiraman , Qing-Bai She , Cailian Liu , Igor Dolgalev , Adriana Heguy , Jedd Wolchok , David Cobrinik , Alan Houghton , Barry Taylor , Neal Rosen , David Solit ,

, B87-B87, 2009-12-01

5 - Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer,

Shuang Zhang , Sonia Iyer , Hao Ran , Igor Dolgalev , Wei Wei , Connor Foster , Robert A. Weinberg , Benjamin G. Neel ,

, 2020-04-07

6 - Abstract 1971: Concurrent loss of PTEN and RB is sufficient to confer BRAF independence in melanomas harboring V600E BRAF mutations,Cancer Research

Feng Xing , Yogindra Persaud , Christine Pratilas , Manickam Janakiraman , Qing-Bai She , Cailian Liu , Igor Dolgalev , Adriana Heguy , Jedd Wolchok , David Cobrinik , Alan Houghton , Barry Taylor , Neal Rosen , David Solit ,

, 1971-1971, 2010-04-01

7 - Next-Generation Sequencing Suggests Complex, Heterogeneous Pathogenesis In Peripheral T-Cell Lymphoma Unspecified,Blood

Jonathan H. Schatz , Steven M. Horwitz , Matthew A. Lunning , Igor Dolgalev , Kety Huberman , Adriana Heguy , Agnes Viale , Nicholas D. Socci , Mono Pirun , Julie Teruya-Feldstein , Hans-Guido Wendel ,

, 843-843, 2013-11-15

8 - Abstract 6448: Oral cancer pain mediators released in exosomes are oncogenes with potential to shape the microenvironment and induce neuronal sensitivity,Cancer Research

Aditi Bhattacharya , Zinaida Dubeykoskaya , Huu Tu Nguyen , Igor Dolgalev , Ratna Veeramachaneni , Brian L. Schmidt , Donna G. Albertson ,

, 6448-6448, 2020-08-15

9 - MicroRNA‐125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway,Pigment Cell & Melanoma Research

Lisa Koetz‐Ploch , Douglas Hanniford , Igor Dolgalev , Elena Sokolova , Judy Zhong , Marta Díaz‐Martínez , Emily Bernstein , Farbod Darvishian , Keith T. Flaherty , Paul B. Chapman , Hussein Tawbi , Eva Hernando ,

, 328-338, 2017-04-19

10 - Abstract 3223: Overcome LKB1 mutated cancer resistance to anti-PD1 treatment,Cancer Research

Jiehui Deng , Aatish Thennavan , Yuanwang Pan , Igor Dolgalev , Ting Chen , Heather Silver , Matthew Harris , Val Pyon , Fei Li , Chelsea Lee , Aristotelis Tsirigos , Eli Rothenberg , Charles M. Perou , Kwok-Kin Wong ,

, 3223-3223, 2019-07-01

11 - A Population of Tumor-Infiltrating CD4+ T Cells Co-Expressing CD38 and CD39 Is Associated with Checkpoint Inhibitor Resistance,Clinical Cancer Research

Ankita Mitra , Brian Thompson , Ann Strange , Carol M. Amato , Melinda Vassallo , Igor Dolgalev , Jonathan Hester-McCullough , Tomoaki Muramatsu , Diana Kimono , Amrutesh S. Puranik , Jeffrey S. Weber , David Woods ,

, 4242-4255, 2023-07-28

12 - Data from A Population of Tumor-Infiltrating CD4+ T Cells Co-Expressing CD38 and CD39 Is Associated with Checkpoint Inhibitor Resistance,

Ankita Mitra , Brian Thompson , Ann Strange , Carol M. Amato , Melinda Vassallo , Igor Dolgalev , Jonathan Hester-McCullough , Tomoaki Muramatsu , Diana Kimono , Amrutesh S. Puranik , Jeffrey S. Weber , David Woods ,

, 2023-10-13

13 - Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition,

Wei Wei , Mitchell J. Geer , Xinyi Guo , Igor Dolgalev , Neville E. Sanjana , Benjamin G. Neel ,

, 2022-08-27

14 - Data from A Population of Tumor-Infiltrating CD4+ T-cells Co-expressing CD38 and CD39 is Associated with Checkpoint Inhibitor Resistance,

Ankita Mitra , Brian Thompson , Ann Strange , Carol M. Amato , Melinda Vassallo , Igor Dolgalev , Jonathan Hester-McCullough , Tomoaki Muramatsu , Diana Kimono , Amrutesh S. Puranik , Jeffrey S. Weber , David Woods ,

, 2024-09-16

15 - Data from A Population of Tumor-Infiltrating CD4+ T-cells Co-expressing CD38 and CD39 is Associated with Checkpoint Inhibitor Resistance,

Ankita Mitra , Brian Thompson , Ann Strange , Carol M. Amato , Melinda Vassallo , Igor Dolgalev , Jonathan Hester-McCullough , Tomoaki Muramatsu , Diana Kimono , Amrutesh S. Puranik , Jeffrey S. Weber , David Woods ,

, 2024-09-16

16 - Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian Carcinoma,

Shuang Zhang , Tao Zhang , Igor Dolgalev , Hao Ran , Douglas A. Levine , Benjamin G. Neel ,

, 2018-11-29

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