Wen-Cheng Xiong

Professor Wen-Cheng Xiong is a distinguished faculty member in the Neurosciences Department at Case Western Reserve University's School of Medicine. With a Ph.D. from Johns Hopkins University, obtained in 1994, Professor Xiong has dedicated his career to advancing our understanding of the intricate molecular mechanisms that govern neural development and neurodegeneration, as well as bone homeostasis. His research is particularly focused on the signaling pathways and molecular interactions that are crucial for neuronal axonal pathfinding, with a special emphasis on netrin-1 signaling. This work is pivotal in unraveling the complexities of how neurons navigate and establish connections during development. Additionally, Professor Xiong investigates the regulation of bone morphogenetic protein (BMP) signaling through the neogenin-YAP axis, a study that has significant implications for understanding bone formation and maintenance. Professor Xiong's research extends into the realm of neurodegenerative diseases, where he explores the role of VPS35, a protein implicated in the pathogenesis of these conditions. His work aims to elucidate the molecular underpinnings of diseases such as Alzheimer's, providing insights that could lead to novel therapeutic strategies. Furthermore, he investigates the intriguing connection between Alzheimer's disease and altered bone metabolism, a relatively unexplored area that holds promise for new discoveries. In addition to his work on neurodegeneration, Professor Xiong is deeply interested in the function of LRP4 in bone homeostasis. His research in this area seeks to understand how this receptor contributes to the regulation of bone density and strength, potentially offering new avenues for treating bone-related disorders. Through his comprehensive research endeavors, Professor Wen-Cheng Xiong continues to contribute significantly to the fields of neuroscience and bone biology, fostering a deeper understanding of the molecular processes that underlie health and disease. His work not only advances scientific knowledge but also holds the potential to impact clinical practices and improve patient outcomes in the future.