Mack Wu

Dr. Mack Wu is a distinguished Professor of Surgery at the Morsani College of Medicine, University of South Florida. He embarked on his medical journey at the Second Military Medical University, where he earned his medical degree in 1984. Over the years, Dr. Wu has carved a niche in the field of molecular pathophysiology, particularly focusing on barrier tissues such as the microvascular endothelium and intestinal epithelium. His research is centered on understanding the complex mechanisms that lead to conditions like leaky gut, especially in the context of trauma, burns, and ischemia-reperfusion injury. Dr. Wu's work delves into the intricacies of signal transduction processes that contribute to microvascular hyperpermeability during inflammatory responses. His investigations extend to the role of focal adhesion kinase and integrin-mediated interactions, which are crucial in the communication between endothelial cells and the extracellular matrix, influencing microvascular function and angiogenesis. Dr. Wu's laboratory is renowned for its comprehensive approach, employing a variety of methodologies including in vivo, in situ, and in vitro techniques. This allows for a detailed examination of microcirculatory dynamics, utilizing intact isolated microvessels and cultured cells to explore molecular-level interactions. His work not only advances the understanding of microvascular function but also contributes to the development of therapeutic strategies for related pathologies. Throughout his career, Dr. Wu has been committed to advancing the field of surgery through both his research and teaching. His contributions have been recognized in numerous publications and presentations at national and international conferences. Dr. Wu continues to mentor the next generation of medical professionals, fostering a culture of inquiry and innovation in his students and colleagues. In addition to his academic and research pursuits, Dr. Wu is actively involved in several professional organizations, where he collaborates with peers to further the field of surgery and medical research. His dedication to his field is evident in his ongoing efforts to bridge the gap between basic science and clinical application, ultimately aiming to improve patient outcomes through enhanced understanding of microvascular and epithelial dynamics.