Maria Spies

Breaking new ground in the field of biochemistry and molecular biology, Maria Spies serves as a Professor at the University of Iowa. Her pioneering research delves into the intricate processes of DNA repair, replication, and homologous recombination, with a keen focus on understanding genome stability. Spies is particularly interested in the molecular mechanisms that govern genome caretaker proteins, exploring their critical roles in cancer development and cell senescence. Her laboratory employs cutting-edge experimental techniques, blending physical and single-molecule biochemistry, to unravel the complex regulation and function of these proteins. Through her work, Spies aims to shed light on the fundamental processes that maintain genomic integrity and how their dysregulation can lead to disease. A significant aspect of her research is the exploration of the interplay between recombination and mismatch repair, which is crucial for maintaining genetic stability. By investigating these interactions, Spies seeks to uncover novel insights that could pave the way for innovative therapeutic strategies. Furthermore, Maria Spies is dedicated to the potential of drug discovery by exploiting the unique features of genome caretaker proteins. Her work not only advances our understanding of these essential biological processes but also holds promise for developing new treatments for cancer and other genetic disorders. Her contributions to the field are marked by a commitment to translating basic scientific discoveries into practical applications that can benefit human health.