Mark Schultz

Dr. Mark Schultz is an esteemed Assistant Professor of Pediatrics at the University of Iowa, where he is a dedicated member of the Stead Family Department of Pediatrics. With a profound interest in the intricate mechanisms of protein homeostasis, Dr. Schultz's research is at the forefront of understanding the genetic underpinnings of rare inherited pediatric disorders. His work is particularly focused on Niemann-Pick type C disease, a complex childhood neurovisceral lysosomal storage disorder that arises from mutations in the NPC1 gene, leading to impaired cholesterol trafficking. In his laboratory, Dr. Schultz employs a multifaceted approach to unravel the complexities of protein folding and degradation in both the brain and liver. Utilizing cutting-edge techniques, his team works with induced pluripotent stem cells (iPSCs), iPSC-derived neurons and hepatocytes, as well as mouse models to gain deeper insights into these processes. Through this innovative research, Dr. Schultz aims to shed light on the molecular mechanisms that contribute to the pathogenesis of Niemann-Pick type C disease. A significant aspect of Dr. Schultz's research is the pursuit of novel therapeutic strategies for Niemann-Pick type C disease and other related lysosomal storage disorders. By focusing on the mechanisms of NPC1 degradation, his work seeks to develop proteostasis modulators that can restore the function of mutated NPC1 proteins. This approach holds promise for advancing the treatment landscape for these challenging conditions. Dr. Schultz's contributions to the field have been recognized through numerous publications and presentations at national and international conferences. His commitment to advancing our understanding of neurovisceral disorders is matched by his dedication to mentoring the next generation of scientists and clinicians. Through his research and teaching, Dr. Schultz continues to inspire and lead efforts toward improving the lives of children affected by these rare genetic diseases. In addition to his research endeavors, Dr. Schultz is actively involved in collaborative projects that aim to translate laboratory findings into clinical applications. His work not only enhances our knowledge of lysosomal storage diseases but also paves the way for the development of targeted therapies that could significantly impact patient care.