Karen Berkowitz

Dr. Karen Berkowitz is an esteemed Associate Professor at Drexel University College of Medicine, where she holds dual appointments in the Biochemistry & Molecular Biology and Obstetrics & Gynecology Departments. Her academic journey and professional endeavors are deeply rooted in the intricate study of mammalian germ cell development. With a keen focus on the molecular mechanisms that drive gametogenesis, Dr. Berkowitz has dedicated her research to unraveling the complexities of meiosis, meiotic recombination, and chromosome segregation. Utilizing the mouse model as a pivotal tool, Dr. Berkowitz investigates the processes that ensure genome integrity during reproduction. Her research is particularly significant in understanding the molecular underpinnings of infertility disorders. By exploring the genetic defects that impair gametogenesis, she aims to elucidate the factors leading to diminished reproductive potential. A notable aspect of Dr. Berkowitz's research is her work on CTF18, a protein that plays a critical role in germline development. Her studies have been instrumental in identifying the function of CTF18 in the separation of homologous chromosomes during meiosis. This work has provided valuable insights into the causes of aneuploidy, a condition that can result in offspring with abnormal chromosome numbers. Through her research, Dr. Berkowitz contributes significantly to the broader understanding of human infertility and reproductive disorders. Her findings not only enhance the scientific community's knowledge of genetic control in gametogenesis and chromosomal segregation but also offer potential pathways for addressing reproductive health challenges. Her dedication to advancing the field of reproductive biology continues to inspire and inform future research directions.