Paolo Pires

Dr. Paolo Pires serves as an Assistant Professor in the Departments of Physiology and Surgery at the University of Arizona. With a keen interest in the intricate mechanisms that govern cerebral blood flow, Dr. Pires is a dedicated member of the Graduate Faculty. His research is primarily centered on the regulation of blood flow to the brain, both in healthy conditions and in the presence of diseases. In his laboratory, Dr. Pires delves into the complex interactions between neurons, astrocytes, and endothelial cells, which collectively orchestrate the process known as neurovascular coupling. This research is crucial for understanding how specific regions of the cerebral cortex receive blood flow, a process that is vital for maintaining cognitive function. Dr. Pires is particularly focused on how neurovascular coupling is disrupted in diseases such as Alzheimer's and hypertension. These conditions are known to contribute to cognitive decline, and his research aims to uncover the underlying mechanisms that lead to these changes. By examining the role of specific receptors in endothelial cells, Dr. Pires' lab seeks to identify potential therapeutic targets that could improve endothelial function and protect brain health. His work is supported by a prestigious research grant from the National Heart, Lung, and Blood Institute, which underscores the significance and potential impact of his research. Through his studies, Dr. Pires hopes to contribute to the development of novel therapies that can mitigate the effects of neurovascular dysfunction in disease states, ultimately aiming to preserve cognitive function and enhance quality of life for affected individuals.