Richard Pomerantz

Richard Pomerantz is a distinguished Professor in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University. With a profound dedication to advancing the field of molecular biology, his research primarily delves into the intricate mechanisms of DNA repair and RNA-transcript mediated DNA repair. His work has significantly contributed to the understanding of how cells maintain genomic integrity, a cornerstone of cellular function and health. Throughout his career, Dr. Pomerantz has made groundbreaking discoveries that have reshaped the landscape of biochemistry. He has identified novel mechanisms that facilitate replication bypass of transcription complexes, a critical process for cellular replication and repair. His pioneering research also uncovered a unique mechanism of nucleotide incorporation involving template slippage, providing new insights into the fidelity and regulation of DNA synthesis. Furthermore, he elucidated the mechanism of microhomology-mediated end-joining (MMEJ) promoted by DNA polymerase q (Polq), a key player in DNA repair pathways. In addition to his research on DNA repair, Dr. Pomerantz is deeply invested in the development of novel DNA and RNA synthetic biotechnologies. His innovative approaches aim to harness the potential of these biotechnologies for therapeutic and industrial applications. His work also explores the complex interplay between RNA and DNA metabolism, seeking to unravel the multifaceted roles these molecules play in cellular processes. Dr. Pomerantz's contributions to the field have been recognized with numerous prestigious awards. He is a recipient of the NIH Pathway to Independence Award, which underscores his potential to lead independent research. He has also been honored with the NIH R00 Award, further acknowledging his significant contributions to biomedical research. His innovative research in breast cancer has earned him the DOD Breast Cancer Breakthrough Award, highlighting the impact of his work on understanding and combating this disease. As a leading figure in his field, Dr. Pomerantz continues to inspire and mentor the next generation of scientists. His commitment to research excellence and innovation remains unwavering, as he strives to unlock new frontiers in biochemistry and molecular biology.