Diana Gil Pagés

Diana Gil Pagés's research defines new horizons for understanding the intricate mechanisms of the immune system, particularly focusing on the adaptive immune response. As an Associate Professor at the University of Missouri, she delves into the complex world of T cell receptors (TCRs) and their pivotal role in immune function. Her work primarily revolves around the TCR-associated CD3 multiprotein complex and the CD3 conformational change (CD3Dc), which are crucial for the activation and regulation of T cells. Pagés's research is characterized by a multi-faceted approach that examines the control mechanisms over CD3Dc from various perspectives, including structural, biochemical, developmental, and physiological. Her emphasis on biochemistry and the function of primary immune cells provides a comprehensive understanding of how these components interact and influence immune responses. This detailed exploration aims to uncover new insights that could lead to innovative therapeutic strategies. One of the primary goals of Pagés's research is to translate her findings into practical in vivo therapies for metastatic cancers. She is particularly interested in the potential of fragment antigen-binding (Fab) fragments, which could offer targeted and effective treatments for cancer patients. Her work in this area is driven by a commitment to advancing cancer immunotherapies and improving patient outcomes. Pagés's research interests are broad yet interconnected, encompassing key areas such as immunology, adaptive immune response, inflammation, antigen presentation, and cancer immunotherapies. Her contributions to these fields are not only advancing scientific knowledge but also paving the way for new therapeutic approaches that could revolutionize the treatment of various diseases. Through her dedication and innovative research, Diana Gil Pagés continues to push the boundaries of what is known about the immune system, offering hope for more effective treatments for cancer and other immune-related conditions. Her work exemplifies the potential of scientific research to make a tangible impact on human health and well-being.