Martin Breuss

Dr. Martin Werner Breuss is an esteemed Assistant Professor in the Department of Pediatrics at the University of Colorado Anschutz Medical Campus. His academic journey and professional achievements have been marked by significant contributions to the field of neurodevelopmental disorders and genomic mosaicism. Dr. Breuss's research is particularly focused on genomic mosaicism, sperm mosaicism, and the intricate processes of neurodevelopment, areas in which he has garnered considerable recognition. In 2020, Dr. Breuss was honored with the ASCINA Young Scientist Award, a testament to his innovative research and dedication to advancing scientific understanding. His work has continued to gain momentum, leading to his recognition as a Boettcher Investigator by the Boettcher Foundation for the period of 2022 to 2025. This prestigious appointment underscores his commitment to groundbreaking research and his potential to make significant contributions to the field. Dr. Breuss's research activities are supported by notable funding, including the Boettcher Investigator 2021 and TM-T-22-117 grants. His scholarly output is extensive, with numerous publications that have advanced the understanding of genomic mosaicism and its implications. Some of his most influential works include "Genomic Mosaicism of the Brain: Origin, Impact, and Utility," which explores the foundational aspects of mosaicism in the brain, and "Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrain," which delves into the cellular intricacies of the human brain. Further contributions by Dr. Breuss include "Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development," a study that integrates various omic approaches to understand cortical development anomalies. His work on "Control-independent mosaic single nucleotide variant detection with DeepMosaic" highlights advancements in variant detection technologies. Additionally, his research titled "Unbiased mosaic variant assessment in sperm: a cohort study to test predictability of transmission" provides insights into the transmission dynamics of mosaic variants. Dr. Breuss's dedication to his research and his contributions to the scientific community continue to inspire and pave the way for future discoveries in the field of neurodevelopmental disorders and genomic mosaicism. His work not only enhances our understanding of these complex areas but also holds promise for developing new diagnostic and therapeutic strategies.