Matthew West

Dr. Matthew S. West is redefining paradigms in the field of cellular biology with his pioneering research on membrane scission by the ESCRT-III complex. As an Associate Professor of Clinical Practice in the General Operations department of the School of Medicine's Neuroscience division at the University of Colorado Denver's Anschutz Medical Campus, Dr. West is at the forefront of understanding the intricate mechanisms that govern cellular membrane dynamics. His research is primarily centered on the regulation of membrane scission by the ESCRT-III complex in yeast, a model organism that provides valuable insights into cellular processes. Dr. West's work specifically investigates the ubiquitin hydrolase, Doa4, and its interactions with key proteins involved in membrane scission, such as Vps20, Snf7, and Bro1. Through his research, he aims to elucidate the complex interplay between these proteins and their collective role in maintaining cellular integrity. In addition to his focus on Doa4, Dr. West explores the role of the Vps4 ATPase in regulating Doa4 function. This aspect of his research seeks to uncover the molecular mechanisms by which Vps4 influences the activity of Doa4, thereby contributing to the broader understanding of membrane scission processes. His work has significant implications for understanding how cells maintain their structural integrity and respond to various physiological challenges. Dr. West's contributions to the field are not only advancing scientific knowledge but also paving the way for potential therapeutic applications. By unraveling the complexities of membrane scission, his research holds promise for developing novel strategies to address diseases associated with cellular membrane dysfunction. As a dedicated educator and researcher, Dr. West is committed to fostering the next generation of scientists. He actively engages with students and colleagues, sharing his expertise and passion for cellular biology. His work continues to inspire and drive innovation in the field, making significant strides in our understanding of cellular processes.