Yongxing He

Professor Yongxing He is an esteemed academic focusing on interdisciplinary studies in biochemistry and molecular biology. Currently an Associate Professor at Lanzhou University in Gansu, he collaborates closely with Professor John Kuriyan at QB3 Berkeley. His research is primarily centered on the regulation mechanisms of non-receptor tyrosine kinases, particularly ZAP-70 and Ack1. Professor He's work involves developing high-throughput assays aimed at screening specific inhibitors for ZAP-70, a critical kinase involved in T-cell receptor signaling. His innovative approach seeks to identify potential therapeutic compounds that can modulate immune responses, which could have significant implications for treating autoimmune diseases and cancers. In addition to his work on ZAP-70, Professor He employs X-ray crystallography to unravel the intricate regulation mechanisms of Ack1 activity. This technique allows him to visualize the three-dimensional structures of proteins at atomic resolution, providing insights into how Ack1 functions and how its activity can be modulated. His findings contribute to a deeper understanding of cellular signaling pathways and their implications in disease. Professor He is committed to leveraging the advanced knowledge and techniques he has acquired at Berkeley to advance drug discovery research in China. He aims to capitalize on the burgeoning pharmaceutical industry's interest in novel compounds, positioning his research at the forefront of innovation in drug development. His work not only enhances scientific understanding but also has the potential to lead to the development of new therapeutic agents. Through his collaborative efforts and dedication to research excellence, Professor He continues to make significant contributions to the field of biochemistry, fostering international partnerships and advancing the global scientific community's understanding of kinase regulation and drug discovery.