Chuan He

Professor integrating diverse disciplines to study the intricate mechanisms of gene expression regulation, Chuan He is a John T. Wilson Distinguished Service Professor in the Department of Chemistry at the University of Chicago. His pioneering research delves into the dynamic processes of RNA and DNA methylation, with a particular focus on the role of N6-methyladenosine (m6A) in regulating gene expression. Professor He's groundbreaking discovery of the first RNA demethylase, FTO, marked a significant advancement in the field, shedding light on the reversible nature of RNA modifications. His work has been instrumental in characterizing the functions of various RNA methylation binding proteins, which play crucial roles in transcriptional and post-transcriptional regulation pathways. Through his innovative research, Professor He has developed novel methods to map RNA and DNA modifications, providing invaluable insights into their functional significance across different biological systems. His contributions have not only expanded our understanding of epigenetic regulation but have also opened new avenues for exploring therapeutic interventions in diseases linked to aberrant methylation patterns. Professor He's interdisciplinary approach combines chemistry, biology, and genomics, enabling a comprehensive exploration of the molecular underpinnings of gene expression. His work continues to inspire and influence the scientific community, driving forward the frontiers of knowledge in the field of gene regulation. In addition to his research, Professor He is committed to mentoring the next generation of scientists, fostering a collaborative and innovative research environment. His dedication to education and research excellence has earned him recognition as a leading figure in the study of dynamic RNA and DNA modifications.