Wayne Miles

Wayne Miles is an esteemed Associate Professor in the Department of Molecular Genetics at Ohio State University, where he has carved a niche in the intricate world of cancer biology. His research is primarily centered on the complex post-transcriptional regulatory networks that influence the transcriptome and proteome within human cancer cells. A significant portion of his work delves into the pivotal roles played by RNA-binding proteins (RBPs) and microRNAs (miRNAs) in the regulation of mRNA translation. Miles is particularly interested in the interactions between RBPs, such as the PUMILIO family, and miRNAs, and how these interactions govern the translation of newly synthesized mRNAs. His research aims to unravel the complexities of these molecular interactions and their implications for cellular function and disease. By understanding these processes, he hopes to shed light on the mechanisms of transcriptional deregulation that occur with the loss of the Retinoblastoma 1 (pRB) tumor-suppressor gene, a critical event in the development of many cancers. To achieve these insights, Miles employs a suite of advanced methodologies, including RBP-RNA capture protocols, RNA sequencing (RNA-seq), and quantitative mass spectrometry. These techniques allow him to meticulously measure transcriptional, post-transcriptional, and proteomic changes across a spectrum of biological samples, ranging from normal human cells to cancer cells and primary patient samples. His work is characterized by a systems biology approach, integrating data from multiple levels of gene expression regulation to build comprehensive models of cellular behavior. Through his research, Wayne Miles contributes to a deeper understanding of the molecular underpinnings of cancer, with the ultimate goal of identifying novel therapeutic targets. His work not only enhances our knowledge of cancer biology but also provides a foundation for the development of innovative strategies to combat this complex disease. As a dedicated educator and researcher, Miles is committed to advancing the field of molecular genetics and inspiring the next generation of scientists.