Xue Han

Xue Han's initiatives have impacted the field of cancer immunotherapy through her pioneering research on immune escape mechanisms in solid tumors and hematologic malignancies. As an Assistant Professor in the Department of Microbial Infection and Immunity at The Ohio State University College of Medicine, she is at the forefront of identifying novel immunomodulatory pathways that hold promise for treating cancer, inflammation, and autoimmune diseases. Her work is particularly focused on understanding the intricacies of immune-related adverse events that arise from cancer immunotherapy, aiming to enhance therapeutic efficacy while minimizing side effects. Dr. Han's research delves deeply into the role of PD-1H (VISTA), a critical checkpoint molecule, in modulating anti-cancer immunity and controlling autoimmune responses. By elucidating the mechanisms by which PD-1H influences immune cell function, her work contributes to the development of more effective cancer immunotherapies. Her laboratory is a hub of innovation and collaboration, comprising a dedicated team that includes a Research Assistant, two Post Doctoral Scholars, and a Visiting Scholar, all working together to push the boundaries of current scientific understanding. Her contributions to the field are not only advancing scientific knowledge but also paving the way for new therapeutic strategies that could revolutionize the treatment of cancer and autoimmune diseases. Dr. Han's research is characterized by a commitment to translating basic scientific discoveries into clinical applications, with the ultimate goal of improving patient outcomes. In addition to her research endeavors, Dr. Han is actively involved in mentoring the next generation of scientists. She is dedicated to fostering a collaborative and inclusive research environment, encouraging her team to pursue innovative ideas and approaches. Her leadership and mentorship have been instrumental in shaping the careers of young researchers, many of whom have gone on to make significant contributions to the field. Dr. Han's work has been recognized through various awards and grants, underscoring the impact of her research on the scientific community. Her dedication to advancing the field of immunology and cancer therapy continues to inspire her colleagues and students alike, making her a respected figure in the academic and research communities.