Cagla Akay-Espinoza

Cagla Akay-Espinoza, MD, serves as a Research Assistant Professor in the Department of Oral Medicine at Penn Dental Medicine. With a keen focus on the molecular intricacies of neurodegenerative diseases, her research primarily addresses Alzheimer Disease and HIV-Associated Neurocognitive Disorders (HAND). Dr. Akay-Espinoza's work delves into the complex roles of oxidative stress, the unfolded protein response (UPR), and neuroinflammation, seeking to unravel their contributions to these debilitating conditions. Her research is particularly centered on the impact of antiretroviral compounds on the central nervous system, where she meticulously examines their potential effects on neurons and astrocytes. This exploration is crucial in understanding how these compounds might influence the progression of neurodegenerative diseases. Furthermore, Dr. Akay-Espinoza investigates the ATF6 arm of the UPR during primary HIV infection of macrophages, aiming to uncover its role in the latency of HIV within tissue reservoirs. Through her research, Dr. Akay-Espinoza aspires to identify biomarkers that could pave the way for personalized medicine approaches. Her ultimate goal is to develop novel therapeutics that target the shared underlying mechanisms of neurodegenerative diseases. Her work is a testament to her commitment to advancing the understanding and treatment of these complex disorders, potentially offering new hope for patients and their families. In addition to her research endeavors, Dr. Akay-Espinoza is actively involved in mentoring students and collaborating with fellow researchers. Her contributions to the field are marked by a dedication to bridging the gap between basic science and clinical application, ensuring that her findings translate into tangible benefits for those affected by neurodegenerative diseases.