Zissimos Mourelatos

Dr. Zissimos Mourelatos is revolutionizing practices in the field of molecular biology and pathology through his pioneering work at the University of Pennsylvania. As a Professor of Pathology and Laboratory Medicine, Dr. Mourelatos leads a dynamic research team dedicated to unraveling the complexities of small regulatory RNPs, RNA interference (RNAi), mRNA translation, and decay. His lab is at the forefront of exploring both the fundamental and applied aspects of these critical biological processes, contributing significantly to our understanding of gene regulation and expression. Under Dr. Mourelatos's guidance, the lab has made substantial strides in elucidating the mechanisms by which small regulatory RNPs influence cellular function. His research delves into the intricate pathways of RNAi, a process that plays a crucial role in gene silencing and regulation. By investigating these pathways, Dr. Mourelatos and his team aim to uncover novel insights that could lead to advancements in therapeutic strategies for various diseases. The lab's collaborative environment fosters innovation and discovery, with team members like Nicholas Vrettos, a Research Associate, focusing on the protein components of the germline-specific piRNA silencing pathway. This research is crucial for understanding how piRNAs contribute to genome stability and protect against transposable elements, particularly in the germline. Former Research Associate Panagiotis Alexiou has also contributed significantly to the lab's mission by studying small regulatory RNPs and RNAi. His work has helped to expand the knowledge base surrounding these molecules and their impact on cellular processes. Dr. Mourelatos's lab is committed to pushing the boundaries of what is known about RNA biology, with a particular emphasis on the translational potential of their findings. By bridging the gap between basic research and clinical applications, the lab aims to pave the way for new diagnostic and therapeutic approaches that could revolutionize the treatment of genetic and infectious diseases.