Carl Grunfeld

Dr. Carl Grunfeld serves as the Chief of the Metabolism and Endocrine Sections at the Department of Veterans Affairs Medical Center in San Francisco. He is also a distinguished Professor in the Department of Medicine at the University of California, San Francisco. His research is primarily centered on the intricate metabolic disturbances that occur during infections, with a particular emphasis on alterations in lipid metabolism and energy balance. In his laboratory, Dr. Grunfeld delves into the physiological consequences of the host's response to infection. His work is pivotal in defining cytokine mediators and uncovering the cellular and molecular foundations of these metabolic changes. Through his research, Dr. Grunfeld and his team have identified key regulatory mechanisms in lipid-synthesizing enzymes and associated proteins. They have also explored the role of lipoproteins in neutralizing toxic bacterial fragments, providing significant insights into the body's defense mechanisms. Dr. Grunfeld's contributions extend to the field of AIDS research, where he has played a crucial role in understanding the phenomenon of wasting and developing targeted therapies. His work has also led to the identification of Uncoupling Protein 2 as a potential molecule involved in generating fever during infection responses, shedding light on the body's thermoregulatory processes. His primary thematic area of research lies in Vascular & Cardiac Biology, where he investigates the complex interactions between metabolic pathways and cardiovascular health. Additionally, Dr. Grunfeld maintains a secondary focus on Immunology, exploring the immune system's role in metabolic regulation and disease. His research continues to advance our understanding of the intricate connections between metabolism, infection, and overall health.