Philip J Farabaugh

Professor at Natural Sciences, University of Maryland-Baltimore County0 Followers

Passionate about exploring solutions for cellular translation fidelity, Philip J. Farabaugh is a distinguished Professor in the Department of Biological Sciences at the Natural Sciences University of Maryland-Baltimore County. With a Ph.D. in Biochemistry from Harvard University, he has honed his expertise through postdoctoral research in Genetics at Cornell University. His academic journey has been marked by a deep commitment to unraveling the complexities of RNA translation and the errors that can occur during this critical biological process. Professor Farabaugh's research is primarily centered on understanding how cells mitigate mistakes in translating RNA into proteins. His work delves into the intricacies of translational errors, such as frameshifting and misreading, which can have significant implications for cellular function and health. Through his research, he has identified key mechanisms that contribute to these errors and has explored how cells regulate their frequency to maintain protein synthesis accuracy. In addition to his research, Professor Farabaugh is dedicated to education, teaching a variety of courses in molecular genetics at both undergraduate and graduate levels. His teaching philosophy emphasizes the integration of cutting-edge research with foundational knowledge, preparing students to tackle complex biological questions with a critical and innovative mindset. Throughout his career, Professor Farabaugh has been recognized for his contributions to the field through numerous contracts, fellowships, and grants. These accolades underscore his commitment to advancing our understanding of genetic translation and its implications for cellular biology. His work not only enhances the scientific community's knowledge but also inspires the next generation of researchers to pursue excellence in the life sciences. Professor Farabaugh's dedication to both research and teaching exemplifies his passion for biology and his desire to foster a deeper understanding of the molecular mechanisms that underpin life. His contributions continue to shape the field of molecular genetics, offering insights that have the potential to inform therapeutic strategies and improve human health.

Research Interests

RNA translation translational errors frameshifting misreading protein synthesis accuracy genetic translation mechanisms molecular genetics

Publications

1 - Opt-out Testing Pilot for Sexually Transmitted Infections Among Immigrant Detainees at 2 Immigration and Customs Enforcement Health Service Corps–Staffed Detention Facilities, 2018,Public Health Reports®

Edith Lederman , Andria Blackwell , Gina Tomkus , Misty Rios , Brent Stephen , Ada Rivera , Philip Farabaugh ,

, 82S-89S, 2020-07-01

2 - A high percentage of Euplotes genes require a +1 translational frameshift for expression,Journal of Eukaryotic Microbiology

LAWRENCE A. KLOBUTCHER , MATTHIAS MOLLENBECK , MICHAEL C. GAVIN , PHILIP J. FARABAUGH ,

, 2005-03-01

3 - A comprehensive analysis of translational missense errors in the yeastSaccharomyces cerevisiae,RNA

Emily B. Kramer , Haritha Vallabhaneni , Lauren M. Mayer , Philip J. Farabaugh ,

, 1797-1808, 2010-07-22

4 - Posttranscriptional modification to the core of tRNAs modulates translational misreading errors,RNA

Sima Saleh , Philip J. Farabaugh ,

, 37-51, 2023-10-31

5 - The frequency of translational misreading errors in E. coli is largely determined by tRNA competition,RNA

Emily B. Kramer , Philip J. Farabaugh ,

, 87-96, 2006-11-09

6 - Saturation mutagenesis of a +1 programmed frameshift-inducing mRNA sequence derived from a yeast retrotransposon,RNA

Carla Guarraia , Laura Norris , Ana Raman , Philip J. Farabaugh ,

, 1940-1947, 2007-09-19

7 - Glucose signalling pathway controls the programmed ribosomal frameshift efficiency in retroviral‐like element Ty3 in Saccharomyces cerevisiae,Yeast

Sezai Türkel , Güliz Kaplan , Philip J. Farabaugh ,

, 799-808, 2011-10-12

8 - Accuracy modulating mutations of the ribosomal protein S4-S5 interface do not necessarily destabilize the rps4-rps5 protein–protein interaction,RNA

Haritha Vallabhaneni , Philip J. Farabaugh ,

, 1100-1109, 2009-04-22

9 - Transfer RNA modifications that alter +1 frameshifting in general fail to affect −1 frameshifting,RNA

JAUNIUS URBONAVIC̆IUS , GUILLAUME STAHL , JÉRÔME M.B. DURAND , SAMIA N. BEN SALEM , QIANG QIAN , PHILIP J. FARABAUGH , GLENN R. BJÖRK ,

, 760-768, 2003-06-01

10 - The problem of genetic code misreading during protein synthesis,Yeast

Kartikeya Joshi , Ling Cao , Philip J. Farabaugh ,

, 35-42, 2019-01-01

11 - Mutations of ribosomal protein S5 suppress a defect in late-30S ribosomal subunit biogenesis caused by lack of the RbfA biogenesis factor,RNA

Stefan Nord , Monika J. Bhatt , Hasan Tükenmez , Philip J. Farabaugh , P. Mikael Wikström ,

, 1454-1468, 2015-06-18

12 - An evolutionarily conserved phosphoserine-arginine salt bridge in the interface between ribosomal proteins uS4 and uS5 regulates translational accuracy in Saccharomyces cerevisiae,Nucleic Acids Research

Kartikeya Joshi , Brooke Luisi , Grant Wunderlin , Sima Saleh , Anna Lilly , Temiloluwa Okusolubo , Philip J Farabaugh ,

, 3989-4001, 2024-02-10

13 - The Origins of Gene Instability in Yeast,Science

G. Shirleen Roeder , Philip J. Farabaugh , Deborah T. Chaleff , Gerald R. Fink ,

, 1375-1380, 1980-09-19

14 - Connection between stop codon reassignment and frequent use of shifty stop frameshifting,RNA

Haritha Vallabhaneni , Hua Fan-Minogue , David M. Bedwell , Philip J. Farabaugh ,

, 889-897, 2009-03-27

15 - Studies of translational misreading in vivo show that the ribosome very efficiently discriminates against most potential errors,RNA

Nandini Manickam , Nabanita Nag , Aleeza Abbasi , Kishan Patel , Philip J. Farabaugh ,

, 9-15, 2013-11-18

16 - Three Genes Are Required for trans-Activation of Ty Transcription in Yeast,Genetics

Fred Winston , Catherine Dollard , Elizabeth A Malone , Jeffrey Clare , James G Kapakos , Philip Farabaugh , Patricia L Minehart ,

, 649-656, 1987-04-01

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