Paul Fisher

Dr. Paul Fisher's projects emphasize collaborative solutions for advancing our understanding of cellular and molecular mechanisms that underpin human health. As a Professor and Vice-Chairman in the Department of Pharmacological Sciences at Stony Brook University Medical School, Dr. Fisher is at the forefront of research into the intricate world of nuclear structure and function. His work is particularly focused on the role of extrachromosomal proteinaceous structural elements, which are pivotal in regulating these nuclear processes. In his laboratory, Dr. Fisher leads a team that delves into the complexities of major karyoskeletal polypeptides and DNA polymerases. His research is groundbreaking in the field of site-specific DNA damage repair mechanisms, a critical area for understanding how cells maintain their integrity and prevent diseases such as cancer. By exploring these mechanisms, Dr. Fisher aims to uncover new therapeutic targets and strategies for enhancing DNA repair processes. Dr. Fisher's research also extends into the realm of neurodegenerative diseases, with a specific focus on a human protein associated with spinocerebellar ataxia. This work is crucial for developing a deeper understanding of the molecular basis of neurodegeneration and could lead to innovative treatments for these debilitating conditions. His studies utilize a variety of model systems, including yeast, fruit flies, and vertebrate cells, allowing for a comprehensive approach to investigating these fundamental cellular processes. With a strong commitment to interdisciplinary collaboration, Dr. Fisher's research not only advances scientific knowledge but also has significant implications for improving human health. His work is characterized by a meticulous approach to understanding the molecular underpinnings of disease, and he is dedicated to translating these findings into practical applications. Dr. Fisher's contributions to the field of pharmacological sciences are widely recognized, and his research continues to inspire new generations of scientists. Through his leadership and innovative research, he is helping to pave the way for future breakthroughs in the understanding and treatment of complex diseases.