Michael Przybilla

Assistant Professor at Genetics, University of Minnesota-Twin Cities0 Followers

Michael Przybilla's innovative methodologies enhance understanding of genetic diseases, particularly lysosomal disorders. As an Assistant Professor in the Department of Pediatrics, Division of Pediatric Genetics & Metabolism at the University of Minnesota, Dr. Przybilla is dedicated to advancing the field of therapeutic development. He earned his PhD in Molecular, Cellular, Developmental Biology & Genetics from the same institution, which laid the foundation for his groundbreaking work in gene therapy and therapeutic interventions. Dr. Przybilla's research is centered on lysosomal diseases, where he is at the forefront of developing animal models and pioneering novel therapies. His work includes enzyme replacement therapy, small molecule chaperones, gene therapy, and gene editing. These approaches aim to address the underlying genetic causes of lysosomal disorders, offering hope for more effective treatments. Currently, Dr. Przybilla is focused on developing a gene therapy that holds the potential to treat multiple lysosomal diseases. This ambitious project involves collaboration with various research groups, emphasizing the importance of interdisciplinary efforts in preclinical studies for therapeutic development. His work not only contributes to the scientific community but also aims to improve the quality of life for patients affected by these challenging conditions. Dr. Przybilla's expertise in therapeutic development is widely recognized, and his contributions to the field have been instrumental in advancing our understanding of genetic diseases. His commitment to research and collaboration underscores his dedication to finding innovative solutions for lysosomal disorders. Through his work, Dr. Przybilla continues to push the boundaries of what is possible in genetic research, striving to translate scientific discoveries into tangible benefits for patients. His efforts exemplify the critical role of academic research in addressing complex medical challenges and improving healthcare outcomes.

Research Interests

Lysosomal diseases gene therapy enzyme replacement therapy small molecule chaperones gene editing therapeutic development animal models genetic diseases

Publications

1 - CRISPR-mediated genome editing to treat MPS I mice with AAV vectors,Molecular Genetics and Metabolism

Li Ou , Michael Przybilla , Chester Whitley ,

, S112, 2018-02-01

2 - Metabolomics profiling of mice and patients with Sandhoff disease to identify biomarkers,Molecular Genetics and Metabolism

Li Ou , Michael Przybilla , Chester Whitley ,

, S112, 2018-02-01

3 - Proteomics and interactomics analysis of brain samples from MPS mice and patients,Molecular Genetics and Metabolism

Li Ou , Michael Przybilla , Chester Whitley ,

, S112-S113, 2018-02-01

4 - Establishing genotype-phenotype corrleation of lysosomal diseases with in silico tools,Molecular Genetics and Metabolism

Li Ou , Michael Przybilla , Chester Whitley ,

, S112, 2018-02-01

5 - Phenotype prediction for mucopolysaccharidosis type I by in silico analysis,Orphanet Journal of Rare Diseases

Li Ou , Michael J. Przybilla , Chester B. Whitley ,

, 2017-07-04

6 - Proteomic analysis of mucopolysaccharidosis type I mouse brain with two-dimensional polyacrylamide gel electrophoresis,Molecular Genetics and Metabolism

Li Ou , Michael J Przybilla , Chester B Whitley ,

, S104, 2017-01-01

7 - Utilizing CRISPR/Cas9 genome editing to generate a novel murine model of GM1 gangliosidosis,Molecular Genetics and Metabolism

Michael J. Przybilla , Li Ou , Chester B. Whitley ,

, S121, 2018-02-01

8 - Proteomic analysis of mucopolysaccharidosis I mouse brain with two-dimensional polyacrylamide gel electrophoresis,Molecular Genetics and Metabolism

Li Ou , Michael J Przybilla , Chester B Whitley ,

, 101-110, 2017-01-01

9 - Fetal accumulation of glycosaminoglycan in a mouse model of Hurler syndrome,Molecular Genetics and Metabolism

Michael J. Przybilla , Li Ou , Chester B. Whitley ,

, S121, 2018-02-01

10 - Cross coupling between lightning conductor and signal lines within rotor blades,2015 IEEE International Symposium on Electromagnetic Compatibility (EMC)

Matthias Hampe , Olaf Berndt , Michael Przybilla , Birgit Wieland ,

, 355-360, 2015-08-01

11 - Metabolomics profiling reveals profound metabolic impairments in mice and patients with Sandhoff disease,Molecular Genetics and Metabolism

Li Ou , Michael J. Przybilla , Chester B. Whitley ,

, 151-156, 2019-02-01

12 - Optimal stoichiometry of CRISPR-Cas9 components in the PS Gene-editing System,Molecular Genetics and Metabolism

Michael J. Przybilla , Hanna Saveraid , Li Ou , Chester B. Whitley ,

, 108005, 2024-02-01

13 - RTB lectin-mediated delivery of lysosomal α- l -iduronidase mitigates disease manifestations systemically including the central nervous system,Molecular Genetics and Metabolism

Li Ou , Michael J. Przybilla , Brenda Koniar , Chester B. Whitley ,

, 105-111, 2018-02-01

14 - SAAMP 3.0©: Computational biology to predict the phenotype of a missense mutation for lysosomal diseases,Molecular Genetics and Metabolism

Xinze Tan , Xiangyu Zhang , Michael Przybilla , Chester B. Whitley , Li Ou ,

, S150, 2020-02-01

15 - Gene editing to treat GM1-gangliosidosis by heterotopic insertion of GLB1 in a murine model,Molecular Genetics and Metabolism

Michael Przybilla , Li Ou , Jeanine R. Jarnes-Utz , Chester B. Whitley ,

, S131, 2020-02-01

16 - Immunogenicity, genotoxicity, and efficacy of PS gene editing in treating MPS I mice,Molecular Genetics and Metabolism

Li Ou , Michael Przybilla , Sarah Kim , Gerard O'Sullivan , Chester B. Whitley ,

, S81, 2021-02-01

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